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RBD-GWAS-analysis

Code for the paper: Genome-wide association study of REM sleep behavior disorder identifies novel loci with distinct polygenic and brain expression effects

Background

Background

This repository contains scripts used to perform a colocalisation analysis using the REM sleep behavior disorder (RBD) GWAS and two eQTL datasets:

Citation

If you use any of the code or data from this repository, please cite our paper.

License

The code published here, and in the associated GitHub repository, is released under an MIT license. It is distributed in the hope that it will be useful to the wider community, but without any warranty of any kind. Please see the LICENSE file for more details.

Code contents

Scripts and results of analyses have been described in the following workflows:

  1. RBD_coloc: details coloc set up and analysis of results.
  2. RBD_coloc_tissue_cell_specificity: details tissue- and cell-type-specificity of genes identified by coloc.
  3. RBD_manuscript_figures: details code used to produce manuscript figures pertaining to coloc analyses.

Contact

If you spot any bugs in this code or run into any faulty links, please raise an issue on the associated GitHub repository.